Pub. Date : 1993 Nov 30
PMID : 7504525
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An active FK506-binding domain of 17,000 daltons is isolated following limited proteolysis of chicken thymus hsp56. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 2 | We now report that hsp56 is also found to be a major immunophilin in chicken thymus, by virtue of binding to FK506-Affi-Gel-10 as well as positive cross-reactivity with a polyclonal antiserum directed against human hsp56. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 3 | Peptide mapping provided additional proof that p17 is a fragment which comprises the entire FK506 binding domain I of chicken hsp56, terminating with an Arg-Lys which might represent a processing site. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |
| 4 | This work demonstrates the excision of a domain from an hsp56 protein that is active in binding FK506 and functionally distinct from FKBP-12, a protein of similar size and structure. | Tacrolimus | FKBP prolyl isomerase 4 | Homo sapiens |