Title : Interleukin 1 beta-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A.

Pub. Date : 1995 Nov 13

PMID : 7488131






4 Functional Relationships(s)
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1 Here we report that cyclosporin A (CsA) a potent immunosuppressive drug, inhibits IL-1 beta dependent iNOS expression in renal mesangial cells. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
2 Here we report that cyclosporin A (CsA) a potent immunosuppressive drug, inhibits IL-1 beta dependent iNOS expression in renal mesangial cells. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
3 Western- and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by CsA is due to decreased iNOS protein and iNOS mRNA steady state levels. Cyclosporine nitric oxide synthase 2 Rattus norvegicus
4 Western- and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by CsA is due to decreased iNOS protein and iNOS mRNA steady state levels. Cyclosporine nitric oxide synthase 2 Rattus norvegicus