Title : Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance.

Pub. Date : 1995 Nov 2

PMID : 7488097






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The ATP-dependent glutathione S-conjugate export pump (GS-X pump) has been suggested to play a role in the mechanism of cisplatin resistance. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens
2 The purpose of this study was to determine the relationship between intracellular glutathione (GSH) levels and GS-X pump activity and whether GS-X pump overexpression results in cisplatin resistance. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens
3 The purpose of this study was to determine the relationship between intracellular glutathione (GSH) levels and GS-X pump activity and whether GS-X pump overexpression results in cisplatin resistance. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens
4 In conclusion, GS-X pump expression is related to cellular GSH metabolism and involved in cisplatin resistance. Glutathione ATP binding cassette subfamily C member 1 Homo sapiens