Title : Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity.

Pub. Date : 1995 Oct 24

PMID : 7488039






5 Functional Relationships(s)
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Protein Name
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1 Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity. sapropterin nitric oxide synthase 3 Homo sapiens
2 Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity. sapropterin nitric oxide synthase 3 Homo sapiens
3 Here, we demonstrated that cys-99 of human endothelial NOS (ecNOS) is critical for BH4 involvement in NOS catalytic activity and stability. sapropterin nitric oxide synthase 3 Homo sapiens
4 Here, we demonstrated that cys-99 of human endothelial NOS (ecNOS) is critical for BH4 involvement in NOS catalytic activity and stability. sapropterin nitric oxide synthase 3 Homo sapiens
5 Mutation of cys-99 to alanine in ecNOS resulted in loss of catalytic activity which could be restored to the level of wild type by adding a high concentration of exogenous BH4 to the crude extract. sapropterin nitric oxide synthase 3 Homo sapiens