Title : Phorbol ester-resistant monoblastoid leukemia cells with a functional mitogen-activated protein kinase cascade but without responsive protein tyrosine phosphatases.

Pub. Date : 1995 Nov 16

PMID : 7478524






1 Functional Relationships(s)
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1 Unlike known TPA-resistant cells whose resistance is mainly due to lack or down modulation of protein kinase C (PKC), UT16 cells showed TPA-induced activation of PKC, Raf-1, and ERK/MAP kinases similar to the parental U937 cells. Tetradecanoylphorbol Acetate Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens