Title : Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.

Pub. Date : 1995 Nov 16

PMID : 7477349






1 Functional Relationships(s)
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1 The coincidence of urotensin-like immunoreactivity with type-2 CRF receptors in brain, and our observation that urocortin is more potent than CRF at binding and activating type-2 CRF receptors, as well as at inducing c-Fos (an index of cellular activation) in regions enriched in type-2 CRF receptors, indicate that this new peptide could be an endogenous ligand for type-2 CRF receptors. Urocortins Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens