Title : N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.

Pub. Date : 1995 Nov

PMID : 7473143






1 Functional Relationships(s)
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1 Inhibition of AMI demethylation by low concentrations of ketoconazole and by anti-3A antibody supports an important role for CYP3A isoforms in mediating this reaction. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens