Title : The irreversible inactivation of thyroid peroxidase by methylmercaptoimidazole, thiouracil, and propylthiouracil in vitro and its relationship to in vivo findings.

Pub. Date : 1978 Sep

PMID : 744122






2 Functional Relationships(s)
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1 A reinvestigation of the mechanism of action of methylmercaptoimidazole, propylthiouracil, and thiouracil on thyroid peroxidase (TPO) was undertaken. Methimazole thyroid peroxidase Rattus norvegicus
2 A preliminary incubation of TPO and H2O2 with methylmercaptoimidazole, propylthiouracil, or thiouracil was carried out in the absence of oxidizable substrates (i.e. I- or guaiacol). Methimazole thyroid peroxidase Rattus norvegicus