Title : Alterations in brain dopamine and serotonin metabolism during the development of tolerance to human beta-endorphin in rats.

Pub. Date : 1978 Dec

PMID : 743624






2 Functional Relationships(s)
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1 The initial injection of beta-endorphin results in increases in the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in neostriatum, as well as increases in the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in hypothalamus and brainstem and a decrease in 5-HIAA in hippocampus. 3,4-Dihydroxyphenylacetic Acid proopiomelanocortin Homo sapiens
2 The initial injection of beta-endorphin results in increases in the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in neostriatum, as well as increases in the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in hypothalamus and brainstem and a decrease in 5-HIAA in hippocampus. 3,4-Dihydroxyphenylacetic Acid proopiomelanocortin Homo sapiens