Title : The isolation of endogenous modulators of the affinity of acetylcholinesterase to cholinergic ligands.

Pub. Date : 1981 Mar

PMID : 7315401






1 Functional Relationships(s)
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1 The dissociation constant of the crude enzyme-edrophonium complex determined in the affinity chromatographic experiments was 1.5 X 10(-5) M and in enzymatic experiments 1.8 X 10(-7) M. It is proposed that there is present in mammalian neuronal tissue a factor that increases the affinity of certain cholinergic ligands to a site other than the catalytic site on AChE. Edrophonium acetylcholinesterase (Cartwright blood group) Homo sapiens