Pub. Date : 1981 Oct
PMID : 7288604
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, the addition of phenelzine produced immediate decrease in cytochrome P-450. | Phenelzine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 2 | This initial decrease was found to be due to the direct binding of phenelzine to the ferrous heme of cytochrome P-450. | Phenelzine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 3 | Further decrease in cytochrome P-450 occurred upon incubation of microsomes with phenelzine in the presence of NADPH. | Phenelzine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 4 | The decrease in cytochrome P-450 with concomitant loss of heme can be partially inhibited by a substrate (aminopyrine) or by an inhibitor (metyrapone) of the microsomal enzymes, indicating the possible involvement of the metabolism of phenelzine to a reactive intermediate. | Phenelzine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 5 | The comparison of the effect of phenelzine to that of phenylhydrazine strengthened the possibility that a reactive metabolic intermediate of phenelzine can cause heme destruction in cytochrome P-450. | Phenelzine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 6 | The comparison of the effect of phenelzine to that of phenylhydrazine strengthened the possibility that a reactive metabolic intermediate of phenelzine can cause heme destruction in cytochrome P-450. | Phenelzine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 7 | Thus, phenelzine exerts its inhibitory action on microsomal drug metabolism most likely by decreasing the cytochrome P-450 content largely through heme destruction. | Phenelzine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |