Title : Investigation of the anti-acetylcholinesterase activities of the antimalarial agent, amodiaquine, and related compounds.

Pub. Date : 1981 Mar

PMID : 7256355






2 Functional Relationships(s)
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Protein Name
Organism
1 Both the protonated diethylamino and phenolic hydroxyl functions of amodiaquine are necessary for interaction with AChE. Hydroxyl Radical acetylcholinesterase (Cartwright blood group) Homo sapiens
2 This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively. Hydroxyl Radical acetylcholinesterase (Cartwright blood group) Homo sapiens