Title : Danazol and gestagen displacement of testosterone and influence on sex-hormone-binding globulin capacity.

Pub. Date : 1982 Jul

PMID : 7201414






4 Functional Relationships(s)
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Compound Name
Protein Name
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1 The interaction of danazol with T binding to sex-hormone-binding globulin (SHBG) was studied with the use of an aqueous two-phase system with polyethylene glycol (PEG) and dextran for equilibrium partition. Danazol sex hormone binding globulin Homo sapiens
2 The low values for SHBG binding capacity that were found during danazol therapy mainly reflect occupation of binding sites by danazol and to a lesser degree a real decrease in protein concentration. Danazol sex hormone binding globulin Homo sapiens
3 The low values for SHBG binding capacity that were found during danazol therapy mainly reflect occupation of binding sites by danazol and to a lesser degree a real decrease in protein concentration. Danazol sex hormone binding globulin Homo sapiens
4 Therapeutic danazol serum levels are 1000 times those of normal female total T levels; and since the affinity to SHBG for danazol was found to be 1/20 that to T one should conclude an almost total occupation of binding sites. Danazol sex hormone binding globulin Homo sapiens