Title : The mutagenicity of 9-hydroxyellipticine and its induction of cytochrome P-448 activity in rat liver microsomes.

Pub. Date : 1982

PMID : 7172416






1 Functional Relationships(s)
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1 Administration of a single dose of the inhibitor of the hepatic mixed function oxidases, 9-hydroxyellipticine (9-OHE), resulted in a marked increase in the cytochrome P-448 catalysed activities of ethoxyresorufin O-deethylase, biphenyl 2-hydroxylase and activation of benzo[a]pyrene to mutagens. Benzo(a)pyrene cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus