Title : Qualitative alterations of cytochrome P-450 in mouse liver microsomes after administration of acrylamide and methylmethacrylate.

Pub. Date : 1978 Oct

PMID : 716947






4 Functional Relationships(s)
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1 Cytochrome P-450 in mouse liver microsomes was characterized by SDS-polyacrylamide gel electrophoresis after intraperitoneal injection of 80 mg phenobarbital, 4.5 and 45 mg acrylamide and 60 and 600 mg methylmethacrylate per kg body weight each day for four days. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
2 The amount of cytochrome P-450 with a molecular weight of 47,000 (MLvMcP-450(47) decreased in the phenobarbital group and in both acrylamide groups. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
3 The cytochrome P-450 form with a molecular weight of 50,000 (MLvMcP-450(50) was significantly increased only in the phenobarbital group. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
4 An increase in the total amount of cytochrome P-450 was only observed following treatment with phenobarbital. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus