Title : Phenformin stimulation of insulin binding to human cultured lymphocytes.

Pub. Date : 1981 Apr-Jun

PMID : 7024393






7 Functional Relationships(s)
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1 Phenformin stimulation of insulin binding to human cultured lymphocytes. Phenformin insulin Homo sapiens
2 The effects of the oral hypoglycemic agent, phenformin, were studied on the binding of 125I-insulin to its receptors in IM-9 human cultured lymphocytes. Phenformin insulin Homo sapiens
3 Three h after the addition of 5 microgram/ml of phenformin to these cells there was detectable stimulation of 125I-insulin binding; maximal effects were seen after 18 h. A detectable effect of phenformin was seen at 1 microgram/ml and maximal effects were seen at 5 microgram/ml. Phenformin insulin Homo sapiens
4 Three h after the addition of 5 microgram/ml of phenformin to these cells there was detectable stimulation of 125I-insulin binding; maximal effects were seen after 18 h. A detectable effect of phenformin was seen at 1 microgram/ml and maximal effects were seen at 5 microgram/ml. Phenformin insulin Homo sapiens
5 These studies demonstrate therefore than phenformin increases the binding of 125I-insulin to human cultured lymphocytes, and raise the possibility that phenformin could act in vivo to regulate insulin receptors. Phenformin insulin Homo sapiens
6 These studies demonstrate therefore than phenformin increases the binding of 125I-insulin to human cultured lymphocytes, and raise the possibility that phenformin could act in vivo to regulate insulin receptors. Phenformin insulin Homo sapiens
7 These studies demonstrate therefore than phenformin increases the binding of 125I-insulin to human cultured lymphocytes, and raise the possibility that phenformin could act in vivo to regulate insulin receptors. Phenformin insulin Homo sapiens