Title : Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase.

Pub. Date : 1981 Feb 17

PMID : 7011378






1 Functional Relationships(s)
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1 Reduced nicotinamide adenine dinucleotide phosphate (NADPH), folate, dihydrofolate, and the inhibitors trimethoprim and methotrexate bind rapidly and reversibly to both dihydrofolate reductase isoenzymes isolated from Escherichia coli RT500. dihydrofolate Dihydrofolate reductase Escherichia coli