Pub. Date : 1980 Dec
PMID : 7004721
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of prostaglandin in the antihypertensive mechanism of captopril in low renin hypertension. | Captopril | renin | Homo sapiens |
| 2 | An unequivocal reduction in blood pressure and significant increase in plasma renin activity and urinary prostaglandin E excretion were found after the captopril administration. | Captopril | renin | Homo sapiens |
| 3 | The changes in blood pressure, plasma renin activity and urinary prostaglandin E excretion induced by captopril were reversed after the inhibition of endogenous prostaglandin synthesis by indomethacin. | Captopril | renin | Homo sapiens |
| 4 | In low renin hypertensive patients who responded to captopril, the hypotensive effect was abolished after th addition of indomethacin, whereas no marked change in blood pressure was induced by indomethacin in normal renin hypertensive patients. | Captopril | renin | Homo sapiens |
| 5 | In contrast, plasma renin activity was markedly increased after captopril administration in normal renin hypertension, and no significant change was found in low renin hypertension. | Captopril | renin | Homo sapiens |
| 6 | In contrast, plasma renin activity was markedly increased after captopril administration in normal renin hypertension, and no significant change was found in low renin hypertension. | Captopril | renin | Homo sapiens |
| 7 | In contrast, plasma renin activity was markedly increased after captopril administration in normal renin hypertension, and no significant change was found in low renin hypertension. | Captopril | renin | Homo sapiens |
| 8 | Potentiation of the prostaglandin system seems to be a principal factor in the antihypertensive mechanism of captopril in low renin hypertension, and inhibition of the renin-angiotensin system is important in normal renin hypertensives. | Captopril | renin | Homo sapiens |
| 9 | The increase in renin release after the administration of captopril was inhibited by indomethacin, suggesting that an endogenous prostaglandin system may contribute to the short feedback mechanism of renin release. | Captopril | renin | Homo sapiens |
| 10 | The increase in renin release after the administration of captopril was inhibited by indomethacin, suggesting that an endogenous prostaglandin system may contribute to the short feedback mechanism of renin release. | Captopril | renin | Homo sapiens |