Title : Cultured hepatoma cells as a model system for studying insulin processing and biologic responsiveness.

Pub. Date : 1980 Nov

PMID : 7000584






1 Functional Relationships(s)
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1 Agents believed to inhibit intralysosomal degradation of various proteins also inhibited the degradation of 125I-insulin by H4 cells (chloroquine, ammonium chloride, procaine, and lidocaine); inhibitors of energy production (dinitrophenol, sodium cyanide) inhibited degradation; an agent which inhibits microtubule function (vinblastine) blocked insulin degradation; and methylamine, reported to prevent receptor aggregation,2 also interfered with insulin processing. Ammonium Chloride insulin Homo sapiens