Title : Effect of cyclosporin A on T cell function in vitro: the mechanism of suppression of T cell proliferation depends on the nature of the T cell stimulus as well as the differentiation state of the responding T cell.

Pub. Date : 1982 Dec

PMID : 6982917






4 Functional Relationships(s)
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Protein Name
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1 CY A suppressed T cell activation by the mitogen, concanavalin A, by blocking IL 2 production and not by blocking the induction of IL 2 receptors. Cyclosporine interleukin-2 Cavia porcellus
2 CY A completely blocked the primary allogeneic MLR but this inhibitory effect could be reversed when exogenous IL 2 was added to the cultures. Cyclosporine interleukin-2 Cavia porcellus
3 Thus, in the guinea pig, CY A inhibits Ti cell activation both by blocking IL 2 production as well as by inhibiting the induction of IL 2 responsiveness. Cyclosporine interleukin-2 Cavia porcellus
4 Thus, in the guinea pig, CY A inhibits Ti cell activation both by blocking IL 2 production as well as by inhibiting the induction of IL 2 responsiveness. Cyclosporine interleukin-2 Cavia porcellus