Title : Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline-sulphinpyrazone interaction.

Pub. Date : 1983 May

PMID : 6860533






1 Functional Relationships(s)
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1 It is proposed that sulphinpyrazone has differential effects on at least two forms of cytochrome P-450 inhibiting one enzyme or group of enzymes which metabolises tolbutamide, phenytoin and S(-)warfarin and inducing a form (or forms) which metabolises theophylline, antipyrine and R(+)warfarin. Theophylline cytochrome P450 family 4 subfamily F member 3 Homo sapiens