Title : Biosynthetic processing of the oligosaccharide chains of cellular fibronectin.

Pub. Date : 1980 Oct 15

PMID : 6774767






5 Functional Relationships(s)
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1 Biosynthetic processing of the oligosaccharide chains of cellular fibronectin. Oligosaccharides fibronectin 1 Homo sapiens
2 The oligosaccharides on fibronectin were analyzed by gel electrophoresis for alterations in sensitivity to the enzyme endo-beta-N-acetylgluosaminidase H, which specifically cleaves the "high-mannose" class of asparagine-linked oligosaccharide. Oligosaccharides fibronectin 1 Homo sapiens
3 Incorporated mannose was removed only at early time points, suggesting that the structure of fibronectin oligosaccharides was altered due to processing. Oligosaccharides fibronectin 1 Homo sapiens
4 We conclude that the carbohydrate portion of fibronectin is synthesized as a "high-mannose" intermediate and is subsequently processed to give the characteristic "complex" oligosaccharide chains of fibronectin. Oligosaccharides fibronectin 1 Homo sapiens
5 We conclude that the carbohydrate portion of fibronectin is synthesized as a "high-mannose" intermediate and is subsequently processed to give the characteristic "complex" oligosaccharide chains of fibronectin. Oligosaccharides fibronectin 1 Homo sapiens