Title : The preferred solution conformation of warfarin at the active site of cytochrome P-450 based on the CD spectra in octanol/water model system.

Pub. Date : 1984 Aug

PMID : 6747992






2 Functional Relationships(s)
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1 On the basis of these results, the hemiketal form is proposed as the preferred solution conformation of warfarin in the lipid environment of the active site of cytochrome P-450 and the relationship between solution conformation and stereoselectivity of warfarin metabolism by beta-naphthoflavone inducible cytochrome P-450 is discussed. beta-Naphthoflavone cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 On the basis of these results, the hemiketal form is proposed as the preferred solution conformation of warfarin in the lipid environment of the active site of cytochrome P-450 and the relationship between solution conformation and stereoselectivity of warfarin metabolism by beta-naphthoflavone inducible cytochrome P-450 is discussed. beta-Naphthoflavone cytochrome P450 family 4 subfamily F member 3 Homo sapiens