Title : Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4.

Pub. Date : 1984 Mar 15

PMID : 6721831






3 Functional Relationships(s)
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1 Oligosaccharides of well-defined molecular size were prepared from heparin by nitrous acid depolymerization, affinity chromatography on immobilized antithrombin III (see footnote on Nomenclature) and gel chromatography on Sephadex G-50. Oligosaccharides serpin family C member 1 Homo sapiens
2 High affinity (for antithrombin III) octa-, deca-, dodeca-, tetradeca-, hexadeca- and octadeca-saccharides were prepared, as well as oligosaccharides of larger size than octadecasaccharide. Oligosaccharides serpin family C member 1 Homo sapiens
3 The inhibition of Factor Xa by antithrombin III was greatly accelerated by all of these oligosaccharides, the specific anti-Factor Xa activity being invariably greater than 1300 units/mumol. Oligosaccharides serpin family C member 1 Homo sapiens