Title : Binding specificity of serum amyloid P component for the pyruvate acetal of galactose.

Pub. Date : 1984 Apr 1

PMID : 6707579






4 Functional Relationships(s)
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1 Although the binding to agarose, a linear galactan hydrocolloid derived from some marine algae, is unlikely per se to be related to the physiological function of SAP, it does provide a model system in which to explore the precise ligand requirements of SAP. Sepharose amyloid P component, serum Homo sapiens
2 We report here that the amount of SAP from human, mouse, and plaice (Pleuronectes platessa L.) serum able to bind to agarose from different sources reflect precisely their pyruvate content. Sepharose amyloid P component, serum Homo sapiens
3 Methylation with diazomethane of the carboxyl groups in the pyruvate moiety of agarose completely abolishes SAP binding to agarose. Sepharose amyloid P component, serum Homo sapiens
4 Methylation with diazomethane of the carboxyl groups in the pyruvate moiety of agarose completely abolishes SAP binding to agarose. Sepharose amyloid P component, serum Homo sapiens