Title : Metabolism of vinylcyclooctane and partition ratio between epoxide formation and cytochrome P-450 destruction.

Pub. Date : 1984 Mar

PMID : 6701911






1 Functional Relationships(s)
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1 Vinylcyclooctane (VCO), which binds to the active site of cytochrome P-450 (P-450) giving a type I difference spectrum, has been found to form the corresponding epoxide as the main metabolite on treatment with liver microsomal monooxygenase obtained from phenobarbital-treated or untreated mice. Phenobarbital cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus