Title : On the function of cytochrome b5 in the cytochrome P-450-dependent oxygenase system.

Pub. Date : 1984 Feb 1

PMID : 6696448






3 Functional Relationships(s)
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1 Such a cytochrome b5-induced structural alteration of the reconstituted enzyme system is accompanied by an increase in affinity of 4-chloroaniline for cytochrome P-450, as measured in terms of cumene hydroperoxide-supported N-oxidation of the arylamine; the maximum velocity of the catalytic process remains unchanged. 4-chloroaniline cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Stopped-flow spectrophotometric studies on the influence of cytochrome b5 on the kinetics of binding to cytochrome P-450 of 4-chloroaniline and/or cumene hydroperoxide show that the rates of formation and decay of the adducts change as the molar ratio of cytochrome b5 to cytochrome P-450 varies. 4-chloroaniline cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 Stopped-flow spectrophotometric studies on the influence of cytochrome b5 on the kinetics of binding to cytochrome P-450 of 4-chloroaniline and/or cumene hydroperoxide show that the rates of formation and decay of the adducts change as the molar ratio of cytochrome b5 to cytochrome P-450 varies. 4-chloroaniline cytochrome P450 family 4 subfamily F member 3 Homo sapiens