Title : The heparin-binding site of antithrombin III. Identification of a critical tryptophan in the amino acid sequence.

Pub. Date : 1984 Jan 25

PMID : 6693405






2 Functional Relationships(s)
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1 Chemical modification of a single tryptophan residue in antithrombin III with dimethyl(2-hydroxy-5-nitrobenzyl)sulfonium bromide blocks heparin binding and the heparin-enhanced inhibition of thrombin without altering the heparin-independent rate of thrombin inhibition (Blackburn, M. N., and Sibley, C. C. (1980) J. Biol. Tryptophan serpin family C member 1 Homo sapiens
2 The site of labeling corresponds to Trp 49, which is located within the disulfide-stabilized loops near the NH2-terminal end of the antithrombin III molecule. Tryptophan serpin family C member 1 Homo sapiens