Title : Effect of Tris buffer on the contractile responses of rat vas deferens.

Pub. Date : 1983 Nov 25

PMID : 6653668






4 Functional Relationships(s)
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1 Effect of Tris buffer on the contractile responses of rat vas deferens. Tromethamine arginine vasopressin Rattus norvegicus
2 Equilibration of rat vas deferens muscle strips in Tris containing Tyrode medium caused a significant increase in sensitivity to KCl, but had no effect on the maximum tension induced by NE or KCl. Tromethamine arginine vasopressin Rattus norvegicus
3 Both F and S components of KCl-induced contractions of rat vas deferens were sensitive to verapamil and these depressant effects were further enhanced in the presence of Tris. Tromethamine arginine vasopressin Rattus norvegicus
4 We conclude that Tris can exert adverse effects on the contractile properties of rat vas deferens, probably via the disturbance of Ca2+-handling by the smooth muscle membrane and possibly by affecting release of norepinephrine. Tromethamine arginine vasopressin Rattus norvegicus