Title : Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit.

Pub. Date : 1983 Sep

PMID : 6631241






4 Functional Relationships(s)
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1 Esterification of cholesterol in rabbit small intestine mucosal microsomes by acyl CoA:cholesterol acyltransferase (ACAT, Ec 2.3.1.26) and mucosal cytosol by cholesterol esterase (EC 3.1.1.13) was studied. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
2 Esterification of cholesterol in rabbit small intestine mucosal microsomes by acyl CoA:cholesterol acyltransferase (ACAT, Ec 2.3.1.26) and mucosal cytosol by cholesterol esterase (EC 3.1.1.13) was studied. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
3 N-(1-oxo-9-octadecenyl)-DL-tryptophan(Z)ethyl ester, an inhibitor of cholesterol absorption, was found to inhibit in vitro ACAT in mucosal microsomes at concentrations of 2-20 nmol/0.5 ml incubation mixture, but had no effect on cholesterol esterase in the cytosol at similar concentrations. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus
4 9: 55-62) indicating mucosal ACAT plays a significant role in cholesterol absorption. Cholesterol sterol O-acyltransferase 1 Oryctolagus cuniculus