Title : Effect of succinylacetone on heme and cytochrome P450 synthesis in hepatocyte culture.

Pub. Date : 1983 Mar 21

PMID : 6617864






1 Functional Relationships(s)
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1 Enhanced induction of delta-aminolevulinate synthase and decreased cytochrome P450 induction may be explained by the succinylacetone-mediated inhibition of porphobilinogen synthase and the subsequent depletion of intracellular heme, since these effects of succinylacetone were reversed by addition of heme. Heme cytochrome P450 family 4 subfamily F member 3 Homo sapiens