Title : Human platelet activation by C3a and C3a des-arg.

Pub. Date : 1983 Aug 1

PMID : 6604123






3 Functional Relationships(s)
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1 However, at lower concentrations (2 X 10(-12) M) C3a did not aggregate platelets directly but exhibited highly significant synergism (two-way analysis of variance P less than 0.0001) with ADP in mediating platelet aggregation and release of serotonin. Adenosine Diphosphate complement C3 Homo sapiens
2 Further C3a and C3a des-arg exhibited synergism with ADP of equal significance in both aggregation and the release reaction. Adenosine Diphosphate complement C3 Homo sapiens
3 The concentrations of C3a required for the platelet-stimulating activity involve relatively small number of molecules per platelet (4,000-10,000 for the synergistic reaction with ADP). Adenosine Diphosphate complement C3 Homo sapiens