Title : Human platelet activation by C3a and C3a des-arg.

Pub. Date : 1983 Aug 1

PMID : 6604123






4 Functional Relationships(s)
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1 C3a liberated from C3 by treatment with C3 convertase (or by trypsin) induced aggregation of gel-filtered human platelets and stimulated serotonin release. Serotonin complement C3 Homo sapiens
2 However, at lower concentrations (2 X 10(-12) M) C3a did not aggregate platelets directly but exhibited highly significant synergism (two-way analysis of variance P less than 0.0001) with ADP in mediating platelet aggregation and release of serotonin. Serotonin complement C3 Homo sapiens
3 C3a and C3a des-arg were equally reactive in mediating platelet aggregation and release of serotonin. Serotonin complement C3 Homo sapiens
4 C3a and C3a des-arg were equally reactive in mediating platelet aggregation and release of serotonin. Serotonin complement C3 Homo sapiens