Title : Regulation of the pro-opiomelanocortin mRNA levels in rat pituitary by dopaminergic compounds.

Pub. Date : 1983 Apr

PMID : 6572972






3 Functional Relationships(s)
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1 Administration of a dopamine receptor antagonist, haloperidol (2 mg/kg per day), to adult female rats resulted in a 3- to 5-fold increase in POMC mRNA level in the NIP. Haloperidol proopiomelanocortin Rattus norvegicus
2 The effect of haloperidol and ergocryptine on POMC mRNA in the NIP is time- and dose-dependent. Haloperidol proopiomelanocortin Rattus norvegicus
3 The elevation of POMC mRNA content in the NIP by haloperidol can be observed as early as 6 hr after treatment. Haloperidol proopiomelanocortin Rattus norvegicus