Title : Inhibition of reagin-mediated PCA reactions in monkeys and histamine release from human leukocytes by human IgG4 subclass.

Pub. Date : 1977

PMID : 65338






3 Functional Relationships(s)
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1 Leukocytes from 11 allergic individuals and from 9 normal subjects sensitized with the serum of allergic patients, were capable of releasing histamine with anti-human IgG4, anti-human IgE, and the specific allergen. Histamine immunoglobulin heavy constant epsilon Homo sapiens
2 Leukocytes from the normal individuals released histamine from 3 to 20% with anti-human IgG4 and from 6 to 30% with anti-human IgE. Histamine immunoglobulin heavy constant epsilon Homo sapiens
3 Moreover, normal leukocytes sensitized with IgG4 myeloma protein or a serum of an allergic patient heated at 56 degrees C for 2 h, released a significant amount of histamine on challenge with anti-human IgG4 whereas no response was obtained with anti-human IgE. Histamine immunoglobulin heavy constant epsilon Homo sapiens