Title : Role of cytochrome P-450 and flavin-containing monooxygenase in the N-hydroxylation of N-methyl-4-aminoazobenzene in rat liver: analysis with purified enzymes and antibodies.

Pub. Date : 1984 Oct

PMID : 6510637






1 Functional Relationships(s)
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1 A competitive inhibitor of FMO, methimazole, inhibited the N-hydroxylation of MAB by 65% in the case of MC-microsomes, and the residual activity was inhibited completely by anti-NADPH-cytochrome P-450 reductase (anti-fPT) antibody. Methimazole cytochrome p450 oxidoreductase Rattus norvegicus