Title : Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers.

Pub. Date : 1984 Nov 30

PMID : 6508804






1 Functional Relationships(s)
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1 In a non-membraneous reconstituted system containing NADPH cytochrome P-450 reductase, a NADPH regenerating system and phospholipids, P-450[buf] exhibited an almost complete substrate stereoselectivity for (+)-isomer 1"-hydroxylation. Phospholipids cytochrome P450 family 4 subfamily F member 3 Homo sapiens