Title : Metabolic activation of 1-naphthol by rat liver microsomes to 1,4-naphthoquinone and covalent binding species.

Pub. Date : 1984 Oct 15

PMID : 6487366






2 Functional Relationships(s)
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1 Metyrapone, SKF 525-A and carbon monoxide all inhibited the metabolism of 1-naphthol to 1,4-naphthoquinone and to covalently bound products suggesting the involvement of cytochrome P-450 in at least one step in the metabolic activation of 1-naphthol to reactive products. 1-naphthol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 Metyrapone, SKF 525-A and carbon monoxide all inhibited the metabolism of 1-naphthol to 1,4-naphthoquinone and to covalently bound products suggesting the involvement of cytochrome P-450 in at least one step in the metabolic activation of 1-naphthol to reactive products. 1-naphthol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus