Title : Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation.

Pub. Date : 1983 Dec

PMID : 6417666






3 Functional Relationships(s)
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Protein Name
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1 The 5-lipoxygenase pathway is activated when PMNs are given arachidonic acid in ethanol and there is extensive metabolism to 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). Arachidonic Acid arachidonate 5-lipoxygenase Homo sapiens
2 However, cells activated by the inflammatory agents N-formyl-Met-Leu-Phe (fMLF) or complement component C5a recruit the 5-lipoxygenase to metabolize exogenous arachidonic acid to 5-HETE and LTB4. Arachidonic Acid arachidonate 5-lipoxygenase Homo sapiens
3 In contrast, PMN stimulation by the ionophore A23187 activates both the membrane phospholipase and the 5-lipoxygenase to produce 5-HETE and LTB4 from endogenous arachidonic acid. Arachidonic Acid arachidonate 5-lipoxygenase Homo sapiens