Title : The use of drugs to dissect the pathway for secretion of the glycoprotein hormone chorionic gonadotropin by cultured human trophoblastic cells.

Pub. Date : 1983 Dec 10

PMID : 6417140






2 Functional Relationships(s)
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1 However, monensin-treated cells secreted hCG subunits that contained endo H-sensitive oligosaccharides of the high mannose (mostly Man5GlcNAc2) and hybrid types rather than the endo H-resistant complex chains synthesized by control cells. Oligosaccharides chorionic gonadotropin subunit beta 5 Homo sapiens
2 hCG subunits bearing Man5GlcNAc2 units accumulated intracellularly, suggesting that the equilibration of intracellular Na+/K+ pools blocked oligosaccharide processing at an intra-Golgi point, perhaps by inhibiting movement of the glycoprotein hormone from the "cis" to the "trans" Golgi compartment. Oligosaccharides chorionic gonadotropin subunit beta 5 Homo sapiens