Title : Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes.

Pub. Date : 1983 Sep

PMID : 6409396






1 Functional Relationships(s)
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1 There are two major R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) activation pathways to 5-fluorouracil, one that is mediated by microsomal cytochrome P-450 oxidation at C-5" of the tetrahydrofuran moiety and one that is mediated by soluble enzymes. Tegafur cytochrome P450 family 4 subfamily F member 3 Homo sapiens