Title : Arachidonate release and phosphatidic acid turnover in stimulated human platelets.

Pub. Date : 1983 Feb 25

PMID : 6401733






1 Functional Relationships(s)
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1 [3H]Glycerol-labeled platelets synthesized phospholipids from [3H]PA at a rate of 0.08-0.3 nmol/min/10(9) cells at 37 degrees C. This rate of [3H]glycerol-PA turnover was not enhanced by thrombin stimulation; thus, PA did not turn over rapidly enough to be an intermediate in the release of several nanomoles of arachidonate from phosphatidylinositol in the first few seconds of stimulation. Glycerol coagulation factor II, thrombin Homo sapiens