Title : The change of DNA structure by specific binding of the cAMP receptor protein from rotation diffusion and dichroism measurements.

Pub. Date : 1984 Dec 1

PMID : 6396081






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Binding of CRP to a 62-bp fragment containing the major site leads to an increase of the rotation time constant from 0.33 to 0.43 microseconds; addition of cAMP to the complex induces a decrease to 0.25 microseconds. Cyclic AMP C-reactive protein Homo sapiens
2 The rotation time constants together with the dichroism amplitudes indicate that binding of CRP to specific sites in the presence of cAMP leads to the formation of compact structures, which are consistent with bending of DNA helices. Cyclic AMP C-reactive protein Homo sapiens