CPRiL

6 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	We evaluated the effect of metformin (N,N-dimethylbiguanide), a biguanide known to be less toxic than phenformin, on insulin binding to its receptors, both in vitro and in vivo.	Metformin	insulin	Homo sapiens
2	We evaluated the effect of metformin (N,N-dimethylbiguanide), a biguanide known to be less toxic than phenformin, on insulin binding to its receptors, both in vitro and in vivo.	Metformin	insulin	Homo sapiens
3	Specific 125I-insulin binding to cultured IM-9 human lymphocytes and MCF-7 human breast cancer cells was determined after preincubation with metformin.	Metformin	insulin	Homo sapiens
4	Metformin significantly increased insulin binding in vitro to both IM-9 lymphocytes and MCF-7 cells; the maximum increment was 47.1% and 38.0%, respectively.	Metformin	insulin	Homo sapiens
5	Metformin treatment significantly increased insulin binding in vivo to monocytes of obese subjects (+ 31%, P less than 0.05) and diabetic patients (+ 63%, P less than 0.01).	Metformin	insulin	Homo sapiens
6	These data indicate that metformin increases insulin binding to its receptors in vitro and in vivo.	Metformin	insulin	Homo sapiens