Pub. Date : 1984 Jun
PMID : 6375797
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Frusemide releases renin in the rat kidney when prostacyclin synthesis is suppressed. | Furosemide | renin | Rattus norvegicus |
| 2 | The effect of inhibiting prostaglandin (PG) synthesis on basal and frusemide-stimulated renin secretion was examined in the rat isolated perfused kidney. | Furosemide | renin | Rattus norvegicus |
| 3 | Although renin secretion was increased during frusemide infusion, there was no significant difference between control (1,806 +/- 384 ng angiotensin I (AI) min-1) and treated (2,310 +/- 554 ng AI min-1) rats (P greater than 0.05). | Furosemide | renin | Rattus norvegicus |
| 4 | These results demonstrate that frusemide-stimulated renin secretion in the rat kidney does not require intact renal PGI2 synthesis and is independent of beta-adrenergic mechanisms. | Furosemide | renin | Rattus norvegicus |