Pub. Date : 1984 Feb
PMID : 6370761
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Time-dependent inhibition of insulin release: suppression of the arginine effect by hyperglycaemia. | Arginine | insulin | Homo sapiens |
| 2 | Brief stimulation of the pancreas with arginine causes a refractory state which reduces the insulin response to subsequent stimulations (time-dependent inhibition). | Arginine | insulin | Homo sapiens |
| 3 | In control subjects, a pair of arginine injections (75 mg/kg) at a 30-min interval resulted in 20% reduction of peak and integrated insulin responses to the second injection. | Arginine | insulin | Homo sapiens |
| 4 | In Type 2 (non-insulin-dependent) diabetic patients and in obese subjects, the inhibitory effect of repeated arginine stimuli was abolished. | Arginine | insulin | Homo sapiens |
| 5 | This induced a three- to fivefold greater insulin response to arginine. | Arginine | insulin | Homo sapiens |
| 6 | When the arginine stimulation was repeated 30 min later, no inhibition was observed, the second insulin response being instead augmented 1.5- to 1.8-fold. | Arginine | insulin | Homo sapiens |