Title : Mechanism of action of the second-generation sulfonylurea glipizide.

Pub. Date : 1983 Nov 30

PMID : 6369967






4 Functional Relationships(s)
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1 The effects of glipizide treatment on insulin sensitivity, glucose-mediated insulin secretion, and glucose utilization were measured in newly diagnosed or untreated patients with noninsulin-dependent diabetes mellitus. Glipizide insulin Homo sapiens
2 The data indicate that the antidiabetic action of glipizide is primarily mediated by a potentiation of insulin action and, to a less significant and more variable degree, by an increase in nutrient-mediated insulin secretion. Glipizide insulin Homo sapiens
3 The data indicate that the antidiabetic action of glipizide is primarily mediated by a potentiation of insulin action and, to a less significant and more variable degree, by an increase in nutrient-mediated insulin secretion. Glipizide insulin Homo sapiens
4 Studies in normal mice and dogs show that glipizide potentiation of insulin action is associated with an increase in plasma membrane insulin receptor number, involves some postreceptor events, and is significantly greater on peripheral uptake of glucose than suppression of hepatic glucose production. Glipizide insulin Homo sapiens