Pub. Date : 1983 Oct
PMID : 6350337
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin normalizes insulin binding to monocytes from obese nondiabetic subjects and obese type II diabetic patients. | Metformin | insulin | Homo sapiens |
| 2 | After metformin administration, an increase in insulin binding to peripheral monocytes was observed in seven of eight obese nondiabetic subjects (3.57 +/- 0.43 to 4.69 +/- 0.59% bound at 10(7) monocytes, mean +/- SEM, P less than 0.01) and in all diabetic patients (3.21 +/- 0.21 to 5.22 +/- 0.34, P less than 0.01). | Metformin | insulin | Homo sapiens |
| 3 | These studies indicate that metformin normalizes the binding of insulin to its receptor in obese subjects and diabetic patients. | Metformin | insulin | Homo sapiens |