Title : Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP.

Pub. Date : 1984 Dec 14

PMID : 6335034






2 Functional Relationships(s)
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1 MPTP is oxidized by brain mitochondrial preparations in a process which is blocked by deprenyl and pargyline, implying catalysis by monoamine oxidase B. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens
2 The present paper demonstrates that pure MAO B isolated from beef liver oxidizes MPTP 38% as fast as benzylamine with a comparable Km value. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine monoamine oxidase B Homo sapiens