Pub. Date : 1984 Jul 17
PMID : 6331509
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A kinetic study of the reaction between human myeloperoxidase, hydroperoxides and cyanide. | Cyanides | myeloperoxidase | Homo sapiens |
| 2 | The binding of cyanide to myeloperoxidase (k1 = (1.30 +/- 0.05) X 10(6) M-1 X s-1) is also regulated by an acid/base group with a pKa of 4.00 +/- 0.05 as is the case with hydrogen peroxide; also, only the protonated uncharged form of cyanide reacts with the enzyme. | Cyanides | myeloperoxidase | Homo sapiens |
| 3 | The binding of cyanide to myeloperoxidase (k1 = (1.30 +/- 0.05) X 10(6) M-1 X s-1) is also regulated by an acid/base group with a pKa of 4.00 +/- 0.05 as is the case with hydrogen peroxide; also, only the protonated uncharged form of cyanide reacts with the enzyme. | Cyanides | myeloperoxidase | Homo sapiens |
| 4 | From their effects on the binding of cyanide to the enzyme it is concluded that chloride and thiocyanate bind to myeloperoxidase only when the acid/base group is protonated. | Cyanides | myeloperoxidase | Homo sapiens |
| 5 | The pH-dependence of the dissociation constant of the myeloperoxidase-chloride complex obtained from the spectral changes induced by chloride is the same as observed in the inhibition by chloride of the binding of cyanide. | Cyanides | myeloperoxidase | Homo sapiens |